Indigestion diseases and treatment

Pathogenesis of Indigetion

It originates from delayed gastric emptying, impaired gastric accommodation to a meal, hypersensitivity to gastric distention, changed duodenal sensitivity to lipids or acid, not normal duodenojejunal movement. It can occur with gastric and duodenal origin.The pathology of dyspepsia includes increased secretions of acids in stomach, intestine and duodenum caused by irritation of gastric mucosa resulting in peptic ulcer. Symptoms of indigestion include
epigastirc pain, heart burn, increased abdominal bloating and intestine and duodenum were by causing irritation of
gastric mucosa resulting in peptic ulcers.

Diagnosis of Indigestion

Endoscopic diagnosis is one of the diagnosis of indigestion. Testing for H pylori infection will help in guiding management in the remainder; between 20% and 60% of those with H pylori infection will have peptic ulcer disease. This is to determine who has peptic ulcer disease or functional dyspepsia

Management and treatment of Indigestion

Initial treatment
Antisecretory drug (H2 receptor blocker such as cimetidine, ranitidine, proton pump inhibitor sch as lansoprazole, omeprazole, )
or
Prokinetic drug (domperidone) if antisecretory treatment fails
Switch treatment if first drug type fails
Resistant cases (failed initial treatment)
H pylori eradication
Sucralfate or bismuth
Antispasmodic agent (such as mebeverine)

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